ONLINE ISSN : 1347-6947
PRINT ISSN : 0916-8451
Bioscience, Biotechnology, and Biochemistry
Vol. 70 (2006) , No. 1 pp.31-37
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Anti-Diabetic Effect of Alkaline-Reduced Water on OLETF Rats.
Dan JIN1)2), Sung Hoon RYU3), Hyun Won KIM3), Eun Ju YANG4), Soo Jung LIM4), Yong Suk RYANG4), Choon Hee CHUNG5), Seung Kyu PARK6) and Kyu Jae LEE6)
1) Department of Microbiology, Wonju College of Medicine, Yonsei University
2) Department of Microbiology and Immunology, Yanbian University College of Medicine
3) Department of Biochemistry, Wonju College of Medicine, Yonsei University
4) Department of Biomedical Laboratory Science and Institute of Health Science, College of Health Science, Yonsei University
5) Department of Internal Medicine, Wonju College of Medicine, Yonsei University
6) Department of Parasitology and Institutes for Basic Medical Science, Wonju College of Medicine, Yonsei University
Alkaline-reduced water (ARW) is known to exert several anti-cancer effects, as well as to scavenge reactive oxygen species (ROS) and reduce blood-glucose levels. This study was performed in order to determine the effects of ARW on the control of spontaneous diabetes in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
We assigned 16 male OLETF rats (4 wk) to two groups: an experimental group, which was given ARW, and a control group, which received laboratory tap water. From week 6 to 32, the body weight, lipid composition, and glucose levels in the blood of the rats were measured. The glucose levels of both groups tended to increase. However, the ARW group's glucose levels were significantly lower than those of the control group after 12 weeks (p<0.05).
The total cholesterol and triglyceride levels in the ARW group were found to be significantly lower than those of the control group during the experimental period.
These results suggest that ARW spurred the growth of OLETF rats during the growth stage, and that long-term ingestion of ARW resulted in a reduction in the levels of glucose, triglycerides, and total cholesterol in the blood.
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To cite this article:
Dan JIN, Sung Hoon RYU, Hyun Won KIM, Eun Ju YANG, Soo Jung LIM, Yong Suk RYANG, Choon Hee CHUNG, Seung Kyu PARK and Kyu Jae LEE, "Anti-Diabetic Effect of Alkaline-Reduced Water on OLETF Rats", Biosci. Biotechnol. Biochem., Vol. 70, 31-37 (2006) .
doi:10.1271/bbb.70.31
JOI JST.JSTAGE/bbb/70.31
Copyright (c) 2006 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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